Tumor Lysis Syndrome

Clinical Pathways promote evidence-based, safe, and high-value care for patients by providing clinical recommendations and standard processes. They are developed by multidisciplinary committees of subject matter experts, informed by a methodical review of available evidence and consensus among committee members.   

Clinical Pathways: 

• TLS risk stratification Algorithm 
• TLS intermediate/high risk Algorithm 
• Tumor Lysis Syndrome (TLS) synopsis (provides care standards employed for this clinical pathway)

Inclusion and exclusion criteria 

Inclusion:  

• Patients with suspected or newly diagnosed or newly relapsed malignancy should be screened for TLS.

Exclusion:  

• Non oncologic diagnoses associated with hyperuricemia (i.e., hemolytic uremic syndrome, chronic renal failure, etc.).

Committee members involved in the development: 

• N. Wood, DO | Department of Hematology, Oncology, and Blood and Marrow Transplantation | Committee Chair  
• K. August, MD, MS | Department of Hematology, Oncology and Blood and Marrow Transplantation | Committee member  
• J. Rilinger, MD | Department of Critical Care Medicine | Committee member  
• A. Hadley, MD | Department of Emergency Medicine | Committee member  
• M. Haywood, DO | Department of Emergency Medicine | Committee member  
• T. Glenski, MD, MSHA, FASA | Department of Anesthesiology and Department of Evidence Based Practice | Committee member 
• J. A. Bartlett, PhD, RN | Department of Evidence Based Practice | Committee member 

Publication dates: 

• Finalized date: 08/03/22 
• Next expected revision date: 08/25

If you have any questions regarding this content or identify a broken link, please email evidencebasedpractice@cmh.edu. 

These pathways do not establish a standard of care to be followed in every case. It is recognized that each case is different, and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare a pathway for each. Accordingly, these pathways should guide care with the understanding that departures from them may be required at times.