Research Studies and Clinical Trials Search
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Bronchopulmonary Dysplasia (BPD): A study of Sildenafil in premature babies to evaluate its safety and ability to prevent pulmonary hypertension
This study is for infants: • Born prematurely • Less than 1 year of age • Have a form of lung disease called bronchopulmonary dysplasia (BPD), that may develop an additional problem called...
This study is for infants: • Born prematurely • Less than 1 year of age • Have a form of lung disease called bronchopulmonary dysplasia (BPD), that may develop an additional problem called pulmonary hypertension.This study will learn more about the safety of a drug called sildenafil which is an approved drug available by prescription for use in adult patients with pulmonary hypertension, but is not approved for use in patients less than 1 year of age. Researchers want to learn more about sildenafil side effects and how well it works to prevent long-term problems of BPD, and the best amount (dose) to give in premature babies with BPD. Pulmonary hypertension may worsen the lung disease, and are currently no medicines available to prevent it. Researchers want to find new ways to prevent long-term problems such as pulmonary hypertension in babies with BPD because infants with those conditions are at a higher risk of dying.
Dystonia: A study using MRI images to potentially predict dystonia in children who experience low oxygen levels and brain injury at birth
There are two groups for this research study: Group 1 • Infants less than 30 days old...
There are two groups for this research study: Group 1 • Infants less than 30 days old • Have a diagnosis of Hypoxic-Ischemic Encephalopathy • Are receiving cooling therapy (hypothermia) • Already having a brain scan (MRI) as part of normal medical care Group 2 • Children who are 18 months - 7 years • Have a diagnosis of Dystonia • Already having a brain scan (MRI) as part of normal medical care The purpose of this research study is to gain information that will be used to help predict which children with low oxygen levels and brain injury at birth may go on to develop dystonia. This could allow for earlier treatments for at-risk children that could help improve their long-term development. This research study will add specialized Magnetic Resonance Imaging (MRI) images to the clinical MRI that babies are already receiving to get more information on their brain networks.
Magnetic Resonance Imaging (MRI): Low-field Bedside MRI in Pediatric and Neonatal ECMO patients
This study is for: -Patients aged 0-17 currently undergoing Extracorporeal Membrane Oxygenation (ECMO) and admitted to the NICU, PICU, or CICU at Children's Mercy...
This study is for: -Patients aged 0-17 currently undergoing Extracorporeal Membrane Oxygenation (ECMO) and admitted to the NICU, PICU, or CICU at Children's Mercy The purpose of this study is: -To determine the feasibility and rates of serious adverse events of performing a portable MRI on subject's on ECMO. -To power calculation for subsequent efficacy study on sensitivity and specificity for detection of acute brain injury utilizing hyperfine MRI versus conventional MRI, CT and/or US.
Neonatal Diseases: A study on genetic risk factors
More and more often, doctors and researchers are understanding that there may be a genetic reason why some infants have a greater risk of becoming sick from certain diseases. Some of these diseases are directly or indirectly caused by germs, including bacteria, viruses or fungi...
More and more often, doctors and researchers are understanding that there may be a genetic reason why some infants have a greater risk of becoming sick from certain diseases. Some of these diseases are directly or indirectly caused by germs, including bacteria, viruses or fungi. If we can identify the genetic links that make some infants more likely to become sick from these germs, we may be able to target treatment to these higher-risk babies in the future, which could prevent severe illness and even death. The study team is looking for genetic differences that might make certain babies more likely to become sick from Necrotizing Enterocolitis (NEC), Bronchopulmonary Dysplasia (BPD) and specific blood infections (Group B Strep and Herpes Simplex) during the birth to 12-month-old period.