Research Studies and Clinical Trials Search
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Amblyopia (Lazy Eye): A study on glasses and eye patches in children 3-12 for treatment
This study is for: • Those ages 3-12 years old • Who have amblyopia (lazy eye) in one eye • And who have normal vision in their good eye...
This study is for: • Those ages 3-12 years old • Who have amblyopia (lazy eye) in one eye • And who have normal vision in their good eye This study will evaluate if treating amblyopia (lazy eye) with glasses and eye patching at the same time improves vision as well as treating amblyopia (lazy eye) first with glasses and then with patching, if needed. This study will also use a small wearable temperature sensor to record actual patch wear time with prescribed patching treatment.
Intermittent Exotropia (IXT): A study on full time eye patching
This study is being done for children: • Between 3 and 8 years old • Have intermittent exotropia (eyes that turn out some of the time) • Have good vision...
This study is being done for children: • Between 3 and 8 years old • Have intermittent exotropia (eyes that turn out some of the time) • Have good vision • Be wearing glasses for at least 2 weeks if needed The goal of this study is see if wearing a patch during 3 months all the time while awake, will help children with Intermittent Exotropia (IXT) to improve eye misalignment (keep their eyes straight); better than not wearing a patch.
Juvenile Idiopathic Arthritis (JIA): A study of tears and blood markers for JIA and uveitis
The longitudinal tears portion of this study is for: • Juvenile Idiopathic Arthritis without Uveitis (JIA-no-U): Diagnosed with JIA (RF-negative, oligoarticular, psoriatic, or undifferentiated) within the last four years and are less than 18 years of age at the time of...
The longitudinal tears portion of this study is for: • Juvenile Idiopathic Arthritis without Uveitis (JIA-no-U): Diagnosed with JIA (RF-negative, oligoarticular, psoriatic, or undifferentiated) within the last four years and are less than 18 years of age at the time of enrollment • or Juvenile Idiopathic Arthritis associated Uveitis (JIA-U): diagnosed with JIA (RF-negative, oligoarticular, psoriatic, or undifferentiated) and uveitis and are less than 18 years of age at the time of enrollment The one time DNA collection for genetics portion of this study is for: • JIA-no-U patients who must be 1) diagnosed with JIA ≥ 4 years and 2) have at least one ophthalmology exam performed after having JIA ≥ 4 years. • or JIA-U patients must be 1) diagnosed with JIA, 2) diagnosed with uveitis, and 3) have at least one ophthalmology exam performed confirming uveitis diagnosis. The main reason for this research study is to help researchers to learn more about children with juvenile idiopathic arthritis (JIA) and/or uveitis (inflammation of the eye), and to help researchers identify who is at the greatest risk for uveitis development. Researchers also hope to discover whether certain markers in a child's tears and blood can better help to determine one's risk for developing uveitis. Investigators hope that early detection of uveitis, regular monitoring for eye disease and complications, and appropriate, timely therapy can improve the quality of life and long-term outcomes of children with arthritis and/or uveitis.
Non-infectious Uveitis: A study trying to predict the response of Methotrexate on non-infectious uveitis using eye testing
This study is for those who are: • less than 18 years of age • patients must have been diagnosed with non-infectious uveitis • patients must be starting Methotrexate for treatment of non-infectious uveitis...
This study is for those who are: • less than 18 years of age • patients must have been diagnosed with non-infectious uveitis • patients must be starting Methotrexate for treatment of non-infectious uveitis The main reason for this research study is to improve the way of selecting treatment for Non-infectious uveitis (NIU) patients who started to have NIU as a child. The study team will look at several different items to improve this process including demographics, eye exams, physical exams, imaging results, blood test results, and other potential risk factors. Pediatric NIU leads to vision-threatening complications or permanent vision loss in 50% of affected children. Methotrexate is the usual first chosen medication that works by suppressing the immune system.